The phosphatase Shp2 modulates tissue homeostasis and lifespan in Drosophila

RUZZI LR; PAGANI MR

Berkeley, CA

Conferencia; Cell Symposia - Stem Cell Energetics; 2014

Elsevier Conferences

Regulation of regenerative processes is essential to maintain tissue homeostasis being critical for longevity. The nonreceptor protein tyrosine phosphatase Shp2 has been implicated in stem cell functions, cancer and signaling of several tyrosine kinases receptors, including EGFR and InR. Despite that, its role on tissue homeostasis and survival remains unclear. Here, we show that loss-of-function alleles of the Drosophila Shp2 homolog corkscrew (csw) extend lifespan, where neurons and the fat body are important for such effect. The expression of a gain-of-function allele in fat body, but not in neurons reduces lifespan compared with control fruit flies. A number of cellular markers in midguts suggest that csw loss-of-function allele delays aging in this tissue. Furthermore, csw mutant flies were more resistant to starvation and high yeast diet. These observations indicate that the phospahatase C SW control lifespan through regulation of homeostasis in adult tissues and metabolism in fat body and neurons.