IFIBIO HOUSSAY 25014
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Unidad Ejecutora - UE
artículos
Título:
Water transport mediated by aquaporins may be altered by a reduced activity of Na+/H+ exchangers in human placenta
Autor/es:
DIETRICH, VALERIA; DAMIANO ALICIA
Revista:
PLACENTA
Editorial:
W B SAUNDERS CO LTD
Referencias:
Lugar: Londres; Año: 2015 vol. 36 p. 1487 - 1489
ISSN:
0143-4004
Resumen:
The intracellular pH (pHi) of syncytiotrophoblasts is regulated, in part, by Na(+)/H(+) exchanger (NHE)-1, NHE-2, and NHE-3. Failures in pHi homeostasis could alter critical cellular functions such as water transport and cell volume. Here, we evaluated whether alterations in syncytiotrophoblast pHi could modify water uptake mediated by aquaporins (AQPs) and the contribution of NHEs to this mechanism. We showed that changes in syncytiotrophoblast pHi did not affect water uptake in the presence of functional NHEs. However, inhibition of NHEs alters transcellular water transport mediated by AQPs in acidosis. These results suggest an interaction between placental AQPs and NHEs in the regulation of water uptake during acidotic states.
