Effect of dehydroepiandrosterone supplementation in a rat model of hypoestrogenism and obesity

CAMPELO ADRIÁN; MASSHEIMER, VIRGINIA

Mar del Plata

Congreso; LXIV Reunión Científica anual de la Sociedad Argentina de investigación Clínica.; 2019

Sociedad Argentina de investigación Clínica.

Obesity is a major worldwide health concern that predisposes individuals to a higher risk of cardiovascular disease (CVD), diabetes and metabolic syndrome. The menopausal period is followed by an increased risk of CVD and is associated with higher rates of overweight and obesity. According to intracrinology, intracellular enzymes may convert dehydroepiandrosterone (DHEA) into active steroids in peripheral tissues without systemic exposure to high estrogens levels, presenting DHEA supplementation as a low risk treatment for menopause.The aim of this study was to analyze the effects of DHEA supplementation in a model of hipoestrogenism and obesity. Four groups (n=5) of ovariectomized Wistar rats were feed with standard diet (ND) (4%fat w/w) or high fat (HF) diet (27%fat w/w) for 8 weeks. Hormonal treatment of rats consisted in daily injectections of vehicle (Cont) or DHEA (1mg/kg day of DHEA). Daily food intake was 165.3±6.8; 201.1±9.1 Kcal/kg (ND; HF p