Angiogenesis regulation: different mechanism of action elicited by progesterone (Pg) and medroxyprogesterone acetate (MPA)

CUTINI PABLO; MASSHEIMER, VIRGINIA

Mar del Plata

Congreso; LXIV Reunión Anual de la SAIC. LI Reunión Anual de la SAFE. XXI Reunión Anual de la SAB. XXXI Reunión Anual de la SAP. Con participación de la AACyTAL, la NANOMEDar y la HCS; 2019

SAIC

In atherosclerosis, the generation of microvessels within the plaques represents a survival option for damaged tissue but would also be associated with the instability of the plaque. The risk/benefit of hormone replacement therapy using natural or synthetic progestins such MPA as an alternative to prevent cardiovascular diseases in menopausal women is controversial. The aim of this work was to evaluate the mechanism of action by which Pg and MPA regulate angiogenesis. Tube formation assay and endothelial cell (EC) culture derived from murine aorta were used to evaluate angiogenesis. Total tube length of vessel segments was quantified using ImageJ software. Both progestogens significantly enhanced the number of tube structures (26%; 46% above control, 100 nM Pg; 100 nM MPA respectively, p