Phospholipase D signaling modulates the inflammatory response during 6-OH dopamine (6-OHDA)-induced neurotoxicity

IGLESIAS GONZÁLEZ PA; GONZÁLEZ PARDO V; SALVADOR GA; URANGA RM

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedades de Biociencias

(605) PHOSPHOLIPASE D SIGNALINGMODULATES THE INFLAMMATORY RESPONSEDURING 6-OH DOPAMINE (6-OHDA)-INDUCEDNEUROTOXICITYPablo Andrés Iglesias González (1), Verónica González Pardo(2), Romina María Uranga (1), Gabriela Alejandra Salvador(1)(1) Instituto de Investigaciones Bioquímicas de Bahía Blanca(INIBIBB). (2) Instituto de Ciencias Biológicas y Biomédicasdel Sur (INBIOSUR).Parkinson?s disease (PD) is the second most commonneurodegenerative disorder related with aging. The deathof dopaminergic neurons triggered by oxidative stress andmitochondrial dysfunction is one pathognomonic characteristicof PD patients.Neuronal exposure to 6-OH dopamine (6-OHDA), a hydroxylatedanalogue of dopamine, constitutes a very usefulstrategy for studying the molecular events associated withneuronal death in PD. Our aim in this study was to characterizethe role of phospholipase D (PLD) signaling during6-OHDA-induced neurotoxicity. The exposure to 6-OHDA (50and 75 µM) induced an increase in reactive oxygen species(p