INBIOSUR   25013
INSTITUTO DE CIENCIAS BIOLOGICAS Y BIOMEDICAS DEL SUR
Unidad Ejecutora - UE
artículos
Título:
β-cyclodextrin coating: improving biocompatibility of magnetic nanocomposites for biomedical applications
Autor/es:
CAMPELO, ADRIÁN; MASSHEIMER, VIRGINIA; BLANCO, MARÍA GABRIELA; ZYSLER, ROBERTO; LASSALLE, VERÓNICA; AGOTEGARAY, MARIELA; GARCÍA, ELBA; DE ROSA, MARÍA JOSÉ
Revista:
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Editorial:
SPRINGER
Referencias:
Año: 2020 vol. 31 p. 22 - 22
ISSN:
0957-4530
Resumen:
The role Beta-cyclodextrin (βCD) on improving biocompatibility on healthy cellular and animal models was studied upon aformulation obtained from the development of a simple coating procedure. The obtained nanosystems were thoroughlycharacterized by FTIR, TGA, atomic absorption spectroscopy, dynamic light scattering and zeta potential, TEM/HR-TEM andmagnetic properties. βCD might interact with the magnetic core through hosting OA. It is feasible that the nanocomposite isformed by nanoparticles of MG@OA dispersed in a βCD matrix. The evaluation of βCD role on biocompatibility wasperformed on two healthy models. To this end, in vivo studies were carried out on Caenorhabditis elegans. Locomotion andprogeny were evaluated after exposure animals to MG, MG@OA, and MG@OA-βCD (10 to 500 μg/mL). The influence ofβCD on cytotoxicity was explored in vitro on healthy rat aortic endothelial cells, avoiding alteration in the results derived fromthe use of transformed cell lines. Biological studies demonstrated that βCD attaching improves MG biocompatibility.