Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anticarcinogenic agents

DELGADO FERMÍN ; VERÓNICA GONZÁLEZ PARDO; MARIANA DENNEHY; MARIELA AGOTEGARAY; BOB BURROW; EVA NICOVA; VIVIANA DORN; DELGADO FERMÍN ; VERÓNICA GONZÁLEZ PARDO; MARIANA DENNEHY; MARIELA AGOTEGARAY; BOB BURROW; EVA NICOVA; VIVIANA DORN

INORGANICA CHIMICA ACTA

ELSEVIER SCIENCE SA

Lugar: Amsterdam; Año: 2019 vol. 494 p. 55 - 64

0020-1693

This report describes the synthesis and characterization of two nickel thiosaccharinate complexes, [Ni(tsac)2(PPh3)2] (1) and [Ni(tsac)2(dppe)]·CH3CN (2), where tsac=thiosaccharinate anion, PPh3=triphenylphosphane and dppe=bis(diphenylphosphanyl)ethane. Elemental analysis, FTIR, 1H, 13C and 31PNMR spectra and single crystal X ray diffraction studies of the complexes are presented. DFT optimizations of thetwo new compounds were performed in order to verify the FTIR vibrational assignations. The two nickel(II)thiosaccharinate complexes consist of mononuclear units in which the Ni atoms are the centre of square-planarcoordination spheres, surrounded by two sulfur thiosaccharinate atoms and two phosphorous atoms from thephosphane ligands. In both complexes, the anions are mono-coordinated to the metal. In the [Ni(tsac)2(PPh3)2]structure, the phosphane moieties are located in trans position. In the [Ni(tsac)2(dppe)] structure, the dppeligand chelates to the metal centre, as expected. Additionally, the superoxide dismutase (SOD) mimetic activityof the complexes was measured and it is reported herein. The effects of the complexes on cell proliferation werealso studied and are described.