INBIOSUR   25013
INSTITUTO DE CIENCIAS BIOLOGICAS Y BIOMEDICAS DEL SUR
Unidad Ejecutora - UE
artículos
Título:
Multi-drug delivery system based on lipid membrane mimetic coated nano-hydroxyapatite formulations
Autor/es:
BENEDINI, LUCIANO A.; SANTILLáN, GRACIELA E.; BENEDINI, LUCIANO A.; SANTILLáN, GRACIELA E.; BALDINI, MóNICA; MESSINA, PAULA V.; BALDINI, MóNICA; MESSINA, PAULA V.; PLACENTE, DAMIáN; LAIUPPA, JUAN A.; PLACENTE, DAMIáN; LAIUPPA, JUAN A.
Revista:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2018 vol. 548 p. 559 - 570
ISSN:
0378-5173
Resumen:
Local delivery systems from an osteoconductive biomaterial are suggested as a promising strategy to avoidsimultaneously peri-implant traumas and to induce tissue regeneration. In this work, it is detailed the design andconstruction of a multi-drug delivery formulation based on lipid membrane mimetic coated nano-hydroxyapatite,LMm/nano-HA, as a bone-specific drug delivery approach. The optimal LMm/nano-HA formulationwas selected after analysing the lipid/nano-HA interaction by dynamic light scattering (DLS), æ-potential,transmission electron microscopy (TEM), polarized optical microscopy (POM), differential scanning calorimetry(DSC) and UV?vis spectroscopy. After the initial screening, Ciprofloxacin and Ibuprofen simultaneous -load and-release efficiency from selected LMm/nano-HA was assessed. pH-responsive kinetic profiles of local drug distributionwere characterized and compared with currently applied systemic doses. Finally, the systems? biocompatibilityand drug released activity were positively validated. The obtained results demonstrated that LMm/nano-HA formulations can represent a valuable multi-modal platform in bone tissue therapies.