CHARACTERIZATION OF CHITOSAN FILMS WITH HIGH CONTENT OF GLYCEROL SUITABLE FOR BIOMEDICAL APPLICATIONS

DEBANDI MV; BERNAL CR; FRANÇOIS NJ

Journal of Tissue Sciene and Engineering

OMICS International

Lugar: Westlake, Los Angeles; Año: 2016 vol. 7

2157-7552

In the present work, chitosan/glycerol blends were used to prepare biodegradable flms with potential application in dermal treatment. While the presence of glycerol gives the hydrating effect, the chitosan characteristics contribute to dermal regeneration. Swelling degree measurements, water vapor permeability determinations, mechanical tests, scanning electronic microscopy and Fourier transform infrared spectroscopy analysis; biodegradability studies, thermogravimetric and differential scanning calorimetry analysis were used to analyze the infuence of the incorporation of signifcant amounts of glycerol in flm properties. The obtained results suggested that the glycerol addition provide the flms with the required properties for the intended application related to dermal treatment. Increasing the glycerol concentration, a cluster effect produced by the glycerol molecules surrounding the macromolecular chains led to a decrease in the swelling degree and an increase in the WVP along with improvements in mechanical properties.