INEDES   24797
INSTITUTO DE ECOLOGIA Y DESARROLLO SUSTENTABLE
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effects of Triclosan on the model organism zebrafish (Danio rerio).
Autor/es:
SAGER, E.; DE LA TORRE, F; ROSSI A
Lugar:
Florianopolis
Reunión:
Simposio; II Karyokinesis Symposium 2020; 2020
Institución organizadora:
Universidade Federal de Santa Catarina UFSC
Resumen:
Triclosan (TCS) is an antibacterial and antifungal agent widely used in personal care products, such as creams, deodorants and toothpastes, among others. One of the main sources of incorporation of TCS into the environment is through the waters of treatment plants and untreated. The zebrafish (D. rerio) is a model organism widely used in ecotoxicological tests to assess the effect of TCS on non-target organisms. The aim of this review was to analyze the state of the art on the effects of TCS on zebrafish in the last 20 years. To do this, a bibliometric analysis and literature review was performed using Google Scholar (https://scholar.google.com/) and Science Direct (https://www.sciencedirect.com/) and articles in English published online were considered. The bibliographic search was carried out using the following combination of keywords: "triclosan-zebrafish? and "triclosan-Danio rerio" from 2000 to 2020. We found 33 papers that were included in the database. Of the total analyzed works, 87% were published in the period 2016-2020, where most of the studies were developed in early stages of zebrafish (68%). The concentrations ranges tested were 8600-0.1 µg TCS L-1, with 10-300 µg TCS L-1 being the most widely used range (56%). The orientation of the effects evaluated was gene expression and ecotoxicogenomics (37%), followed by physiological and endocrin disruption studies (21%). Few studies have focused on prolonged exposure in adults (12%), compared to prolonged studies in early stages of development (44%). This review allows knowing the progress made in the last 20 years on the effects of the TCS in zebrafish, whose studies are primarily aimed at understanding changes in gene expression involved in physiology and metabolomics analysis of lipids and carbohydrates in early fish stages. Although most of the work uses sublethal concentrations, there are still few studies that evaluate environmentally relevant concentrations to study the effects of TCS. This review also highlights the need to increase ecotoxicological research involving adult organisms in zebrafish because they provide a more realistic scenario of the potential risks that fish face due to emerging pollutants such as TCS and allow for the evaluation of differential effects in organs levels on fish.