IFIS - LITORAL   24734
INSTITUTO DE FISICA DEL LITORAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Porous silicon sensor for the detection of Chagas Disease
Autor/es:
LILIANA LASAVE; RAÚL URTEAGA; V. GONZALES; R.R. KOROPECKI; ROBERTO R. ARCE; CLAUDIO L. A. BERLI
Lugar:
Santa Fe
Reunión:
Congreso; Congreso Internacional de Metalurgia y Materiales 14° SAM-CONAMET XIII; 2014
Resumen:
Chagas disease is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi (T. cruzi). This illness affects life expectancy in a broad social spectrum of the population ofSouth and Central America. We present the preliminary results of using porous silicon (PS) functionalized surfaces for real-time and label-free detection of anti-T. cruzi antibodies. To perform thisstudy, we designed a bioaffinity-based optical biosensor consisting of: recombinant antigens of T. cruzi (receptors), anti-T. cruzi antibodies present in hyperimmune rabbit sera (analyte), and asingle layer of self-sustained macroporous silicon (optical transducer).
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