Thermoresponsive nanogels with film-forming ability

WEDEPOHL, STEFANIE; GONZALEZ, VERÓNICA D. G.; SONZOGNI, ANA SOFÍA; CALDERON, MARCELO; MINARI, ROQUE J; PASSEGGI (JR), MARIO C. G.; GUGLIOTTA, LUIS MARCELINO

Polymer Chemistry

The Royal Society of Chemistry

Lugar: Cambridge; Año: 2018 vol. 9 p. 1004 - 1011

1759-9962

Thermoresponsive nanogeles (NG´s) with a film-forming ability could have a great potential in delivery system platforms with a controlled and targeted release of drugs or proteins, such as in topical treatment. This platform offers the opportunity of combining both the high loading capacity of NG dispersion and the delivery capability from a film, which could be previously obtainedor directly formed onto the surface where the release is required. Therefore,this article investigates the synthesis of NG´s based on poly(N-vinylcaprolaptam),a thermoresponsive polymer, and poly(butyl acrylate), which promotes particle coalescence and cohesivity (i.e., film forming). The synthesized NG´s have low cytotoxicity and are able to form flexible and smooth films, conserving the thermoresponsivity of the particulated system. The obtained films loaded with a model protein show delivery profiles responsive to temperature changes.