ICIVET-LITORAL   24728
INSTITUTO DE CIENCIAS VETERINARIAS DEL LITORAL
Unidad Ejecutora - UE
artículos
Título:
Intramammary inoculation of Panax ginseng plays an immunoprotective role in Staphylococcus aureus infection in a murine model
Autor/es:
DALLARD, B.E.; RENNA, M.S.; CALVINHO, L.F.; BARAVALLE, C.; SILVESTRINI, P.* (EQUALLY CONTRIBUTING AUTHORS); ORTEGA, H.H.; PEREYRA, E.A.L.; CALVINHO, L.F.; BECCARIA, C.* (EQUALLY CONTRIBUTING AUTHORS); BARAVALLE, C.; PEREYRA, E.A.L.; DALLARD, B.E.; ORTEGA, H.H.; RENNA, M.S.; BECCARIA, C.* (EQUALLY CONTRIBUTING AUTHORS); SILVESTRINI, P.* (EQUALLY CONTRIBUTING AUTHORS)
Revista:
RESEARCH IN VETERINARY SCIENCE
Editorial:
ELSEVIER SCI LTD
Referencias:
Año: 2017 vol. 115 p. 211 - 220
ISSN:
0034-5288
Resumen:
The immunoprotective effect of Panax ginseng (Pg) extract was investigated in a mouse mastitis model. Lactatingfemale mice were intramammarily inoculated with Pg or placebo, and then were challenged with S. aureus, whileother group was inoculated with S. aureus alone. The number of bacteria recovered from mammary glands wassignificantly lower in Pg-treated S. aureus-infected mice (group I) compared with placebo-treated S. aureusinfectedmice (group II) and S. aureus-infected mice (group III). The mRNA expression of TLR2, TLR4, IL-1α andTNF-α was influenced by treatment; being the transcript levels for all genes higher in group I compared withgroup II and III. Activation of NF-κB and the number of monocytes-macrophages in mammary gland tissue wassignificantly increased in group I compared with group II and III. Pg extract was able to trigger an adequateimmune response to confront an infection demonstrating its protective effect and potential for preventing bovineintramammary infections.