Effects of post-suckling n-3 polyunsaturated fatty acids: Prevention of dyslipidemia and liver steatosis induced in rats by a sucrose rich diet during pre and post-natal life

CHICCO AG; CREUS A; ILLESCA P; HEIN GJ; RODRIGUEZ S; FORTINO A

FOOD & FUNCTION

Royal Society of Chemistry

Lugar: Londres; Año: 2016 vol. 7 p. 445 - 454

2042-6496

Theinteraction between fetal programming and postnatal environment suggests thatthe postnatal diet could amplify or attenuate programmed outcomes. Weinvestigated whether dietary n-3 long-chain polyunsaturated fatty acids (n-3PUFAs) at weaning result in an amelioration of dyslipidemia, adiposity andliver steatosis induced by a sucrose-rich diet (SRD) from the onset of pregnancyup to adulthood. During pregnancy and lactation, dams were fed SRD or thestandard powdered rodent commercial diet (RD). At weaning and until 150 days oflife, male offspring from SRD-dams were divided into two groups and fed SRD orSRD-with-fish oil (corn oil 6%, was partially replaced by fish oil (FO: 5% andCO 1%) forming SRD-SRD or SRD-FO groups. Male offspring from RD-dams continuedwith RD up to the end of the experimental period forming an RD-RD group. Thepresence of FO in the weaning diet showed: - prevention ofhypertriglyceridemia, liver steatosis and the increased lipogenic enzymeactivities caused by a maternal sucrose-rich diet. - complete normalization ofCPT I activity and PPARα protein mass levels. ? a slight and notstatistically significant accretion of visceral adiposity. - limited body fatcontent and reduced plasma free fatty acid levels All these results wereobserved even in the presence of high-sucrose diet challenge after weaning. -SRD-dams breast milk depicted a more saturated fatty acid composition. Theseresults suggest a capacity of n-3 PUFAs to overcome some adverse outcomesinduced by a maternal and post weaning sucrose-diet.