INPA   24560
UNIDAD EJECUTORA DE INVESTIGACIONES EN PRODUCCION ANIMAL
Unidad Ejecutora - UE
artículos
Título:
Dendritic cell maturation and cross-presentation: timing matters!
Autor/es:
ALLOATTI ANDRES; AMIGORENA SEBASTIAN; MAGALHAES JOAO; MAGALHAES JOAO; KOTSIAS FIORELLA; KOTSIAS FIORELLA; ALLOATTI ANDRES; AMIGORENA SEBASTIAN
Revista:
IMMUNOLOGICAL REVIEWS
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2016 vol. 272 p. 97 - 108
ISSN:
0105-2896
Resumen:
As a population, dendritic cells (DCs) appear to be the best cross-presenters of internalized antigens on major histocompatibility complex class I molecules in the mouse. To do this, DCs have developed a number of unique and dedicated means to control their endocytic and phagocytic pathways: among them, the capacity to limit acidification of their phagosomes, to prevent proteolytic degradation, to delay fusion of phagosomes to lysosomes, to recruit ER proteins to phagosomes, and to export phagocytosed antigens to the cytosol. The regulation of phagocytic functions, and thereby of antigen processing and presentation by innate signaling, represents a critical level of integration of adaptive and innate immune responses. Understanding how innate signals control antigen cross-presentation is critical to define effective vaccination strategies for CD8(+) T-cell responses.