Participation of the CD44 receptor and genes implicated in hyaluronan metabolism in cognitive deficit of chronically stressed mice

GENARO A. M.; CASTRO M. M.; PALUMBO M. L.; MORONI A. D.; ALANIZ L. D.

Mar del Plata

Congreso; Reunión anual de Sociedades Biocientíficas; 2019

SAIC; SAFE; SAB; SAP

We demonstrated that chronic mild stress (CMS) induce cognitive deficit and a decrease in hippocampal neurogenesis in Balb/c mice. Furthermore, the glycosaminoglycan hyaluronan (HA) is a key component of the extracellular matrix (ECM) in the brain. HA plays an important role in physiological and pathological process, like neuronal development, synaptic plasticity and neurodegeneration. HA is synthesized by HA synthases (HAS1-3) and degraded by hyaluronidases (Hyal1-3). CD44 is the main receptor for HA and it is related to neurological disorders. The aim of this work was to study the effects of the CMS on learning and memory in female C57BL/6J CD44+/- and the expression of CD44 and genes implicated in the metabolism of HA in the hippocampus of female Balb/c mice. We found a decrease in learning and memory in CD44+/- CMS mice respect to WT and CD44+/- control mice in Y-maze (% spontaneous alternation: p