EGFR ligands expression are modulated by the CFTR chloride channel

MASSIP-COPIZ, M.; MORI, CONSUELO;; ANGEL GABRIEL VALDIVIESO; CLAUZURE M; SANTA COLOMA TA,

Mar del Plata

Congreso; LXIII Reunión de la Sociedad Argentina de Investigación Clínica (SAIC); 2018

) EGFR LIGANDS EXPRESSION ARE MODULATED BYTHE CFTR CHANNELMaría Macarena Massip Copiz1, Angel Gabriel Valdivieso1,Mariangeles Clauzure, Consuelo Mori1, Tomás Santa Coloma11Laboratory of Cellular and Molecular Biology, Institute forBiomedical Research (BIOMED UCA-CONICET),Cystic fibrosis (CF) is an autosomic recessive disease characterizedby mutations in the CFTR (cystic fibrosis transmembrane conduc-RESÚMENES DE LAS COMUNICACIONES 75tance regulator) gene. Interestingly, CFTR functions, not only as aregulated chloride channel, but also as a signaling molecule modulatingdifferent genes. Previously, we found different genes whichare regulated by CFTR expression or activity (p