Oncodriver inhibition and Th1 cytokines cooperate to induce tumor senescence and apoptosis in HER2 and triple negative breast cancer (TNBC)

LEA LOWENFELD; DORIS WIENER; JASHODEEP DATTA ; KRITHIKA KODUMUDI; BRIAN J CZERNIECKI; CINTHIA ROSEMBLIT ; SHUWEN XU; GRACIELA A CREMASCHI

Capital Federal

Congreso; Reunion Conjunta de Sociedades Biomedicas; 2017

Sociedad Argentina de Investigaciones Clínicas

Immune infiltration of breast cancer predicts favorable outcomes. We have described the loss of anti-oncodriver Th1 immunity during breast tumorigenesis. We studied the role that Th1 cytokines may play in the induction of tumor senescence and apoptosis of breast cancer cells.HER2positive cells were sensitive to senescence induction when cultured with IFN-γ and TNF-α in a dose dependent manner measured by β-galactosidase activity (p