Involvement of IL-10 and TGF-β in chronically stressed mice cognitive deficit

ALANIZ, LAURA DANIELA; MORONI, ALEJANDRO DAVID; GENARO, ANA MARÍA; DI ROSSO, MARÍA EMILIA; PALUMBO, MARÍA LAURA

Mar del Plata

Congreso; LXI Reunión Científica de la Sociedad Argentina de Investigación Clínica (SAIC); LXIV Reunión Anual de la Sociedad Argentina de Inmunología (SAI) y XLVIII Reunión Anual de la Sociedad Argentina de Farmacología Experimental (SAFE); 2016

SAIC, SAI, SAFE

In previous reports we found that chronic mild stress (CMS) exposure induces a decrease in learning and memory in femaleBALB/c mice. This cognitive defcit correlated with a decrease in CD4+CD25+FOXP3+and an increase in CD4+CD25-FOXP3+regulatory T cells (Tregs) in CMS mice spleen. No differences in the CD4+CD25+FOXP3+ and CD4+CD25-FOXP3+ Tregswerefound in lymphnodes in stressed mice. Tregs have an important role in maintaining self-tolerance through the inhibition of effector T cells. The main cytokines involved in this mechanism are IL-10 and TGF-β, both released by Treg cells. In this context, the aim of this work was to evaluate the levels of the cytokines IL-10 and TGF-β in CMS mice and its correlation with cognitive defcit. Here, we show that CMS mice presented a poor learning performancein the Y-maze (% spontaneous alternation = control: 63.52 ± 1.93;CMS: 50.46 ± 1.96; p