Effect of selective serotonin reuptake inhibitors on chronic stress-induced immunomodulation and molecular alterations related to EL-4 lymphoma invasion in C57BL/6J mice.

GENARO, A.M.; DI ROSSO, M.E.; GONZALEZ MURANO, M.R.

Mar del Plata

Congreso; LXI Reunión Científica de la Sociedad Argentina de Investigación Clínica (SAIC); LXIV Reunión Anual de la Sociedad Argentina de Inmunología (SAI) y XLVIII Reunión Anual de la Sociedad Argentina de Farmacología Experimental (SAFE); 2016

SAIC, SAI, SAFE

Chronic stress is involved in the onset of specific psychiatric diseases such as major depression. Fluoxetine (F) and sertraline (S), two selective serotonin reuptake inhibitors, are widely used for the treatment of depressive symptoms of cancer patients although there are contradictory evidences about its effects on immunity and neoplastic processes. We have previously reported that both F or S are able to revert chronic stress enhancement of EL-4 lymphoma growth and spontaneous metastasis. In the present work we studied the effect of F or S on chronic stress-induced reduction in T cell proliferation and molecular alterations related to cell invasion. Female C57BL/6J mice were subjected (E) or not (C) to a heterotrophic chronic stress model for five weeks. Chronic administration of F or S reverted chronic stress-induced decrease in T cell proliferation to the selective mitogen Con A evaluated by [3H]-thymidine incorporation (Interaction stress x drug, p