THE IMPACT OF THE PRENATAL STRESS IN THE DEVELOPMENT OF OBESITY

MARIA ROSA GONZALEZ MURANO; ALEJANDRO EMILIANO MERCADO,; ADRIANA LAURA BURGEÑO; YAMILA JUAREZ; ANA MARIA GENARO

Mar del Plata

Congreso; LXI ANNUAL MEETING ARGENTINE SOCIETY FOR CLINICAL INVESTIGATION (SAIC) LXIV ANNUAL MEETING ARGENTINE SOCIETY OF IMMUNOLOGY (SAI) XLVIII ANNUAL MEETING ARGENTINE SOCIETY OF EXPERIMENTAL PHARMACOLOGY (SAFE) VII ANNUAL MEETING ARGENTINE SOCIETY OF NANOMEDICI; 2016

SAIC, SAFE, SAI

According to the ?fetal programming hypothesis􀅏, prenatal exposureto suboptimal intrauterine conditions could predispose theindividual to chronic disease at adult age. 􀀱ver the past decades,obesity has increased its 􀁙orld􀁙ide prevalence. Therefore identifyingthe factors that predispose its development is essential. 􀀫n thepresent 􀁙or􀁍, 􀁙e studied the effect of prenatal stress 􀀊􀀲S􀀋 on thedevelopment of obesity. For this purpose pregnant C􀀗􀀙􀀤L/􀀘􀀬 femalemice 􀁙ere stressed during the last 􀁙ee􀁍 of pregnancy for 􀀔 h daily􀀊from 􀀓􀀒 A􀀯 to 􀀓􀀔􀀋 by placing them in a plastic restraining tube.􀀰on􀀏exposed control pregnant females 􀁙ere left undisturbed duringall the gestation period 􀀊􀀰􀀲S􀀋. At 􀀖th 􀁙ee􀁍 of age, both 􀀲S and􀀰􀀲S offspring 􀁙ere fed 􀁙ith one of the follo􀁙ing diets􀀜 High Fat diet􀀊HF􀀦, 􀀖􀀚􀀒􀀒􀁍cal/􀁍g􀀋 or a standard diet 􀀊S􀀦, 􀀕􀀒􀀒􀀒􀁍cal/􀁍g􀀋. After 􀀓􀀔􀁙ee􀁍s of diet, 􀀲S/S􀀦 males sho􀁙ed no differences in body 􀁙eightcompared to 􀀰􀀲S/S􀀦. 􀀫nstead, 􀀲S/HF􀀦 males gained more body􀁙eight than the 􀀰􀀲S/HF􀀦 􀀊p 􀀞􀀒.􀀒􀀗􀀋. 􀀹ithin the group of 􀀲S males􀁙e observed that those fed 􀁙ith HF􀀦 had more body 􀁙eight thanS􀀦 􀀊p 􀀞􀀒.􀀒􀀒􀀓􀀋. After 􀀓􀀘 􀁙ee􀁍s of diet 􀁙e observed a difference inbody 􀁙eight bet􀁙een 􀀲S/HF􀀦 vs 􀀲S/S􀀦 females 􀀊p􀀞􀀒.􀀒􀀓􀀋. 􀀷nli􀁍emales, 􀀲S/HF􀀦 vs 􀀰􀀲S/HF􀀦 females did not sho􀁙 a difference intheir body 􀁙eight. 􀀹hen 􀁙e performed a glucose tolerance test, 􀁙eobserved that all males 􀀊􀀲S 􀀍 􀀰􀀲S􀀋 fed 􀁙ith HF􀀦 sho􀁙ed a higherarea under the curve than those 􀁙ho 􀁙ere fed 􀁙ith S􀀦 􀀊p􀀞􀀒.􀀒􀀒􀀒􀀒􀀓􀀋.􀀹hile females sho􀁙ed no significant difference. 􀀹e conclude thatthe 􀀲S predisposes the development of obesity in male mice, butthis only happens under the inta􀁍e of a HF􀀦. Furthermore, theseresults suggest that exists a sexual dimorphism response to thedevelopment of obesity after prenatal stress.