DIFFERENTIAL EFFECT BY SEX OF A HIGH FAT DIET IN C57/BL6J MICE BEHAVIOUR AND GLUCIDIC METABOLISM. INFLUENCE OF CHRONIC MILD STRESS.

MARÍA ROSA GONZALEZ MURANO; ANDRÉS PROCHNIK; ANA MARÍA GENARO; MIRIAM RUTH WALD

Mar del Plata

Congreso; LXI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC) LXIV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA (SAI) XLVIII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE FARMACOLOGÍA EXPERIMENTAL (SAFE) VII REUNIÓN ANUAL DE LA SOCIEDAD; 2016

SAIC, SAFE, SAI

In the past decades overweight and obesity have turned into one of the most common non-contagious diseases, currently spreading worldwide. In recent clinical studies obesity has been associated with impairment in cognitive function and even pointed at being a risk factor in the development of dementias, such as Alzheimer?s disease. In the present study we analyze if a high fat diet can lead to behaviour alterations and wether these are associated with metabolic changes. Furthermore, we investigated if stress aggravates these alterations.Male and female C57/BL6J mice were fed with a high fat diet (HFD; 35% w/w) or a standard diet (SD, 5% w/w) during 6 months. Two months after starting the diet, mice under HFD were subdivided in two groups: one received chronical mild stress (CMS) and the other was left undisturbed.relevant to anxiety, context and spacial memory and run a glucose tolerance test. Results shown that mice under HFD had a higher body weight (Male:N=9 p