The thyroid status modulates the 4T1 breast cancer development in vivo through the regulation of cell proliferation, the composition of tumor microenvironment and the antitumor immune response

AMOROS, MARIANA; BOLONTRADE, MARCELA F.; PAULAZO, ALEJANDRA; GARCIA, MARIANA; STERLE, HELENA; HILDEBRANDT, XIMENA; CREMASCHI, GRACIELA

Mar del Plata

Simposio; LXI Reunión Anual SAIC SAI SAFE; 2016

SAIC SAI SAFE

The tumor development is regulated by a wide range of factors, including hormones produced by the endocrine system. However, very little is known about the influence of thyroid hormone (TH) levels on tumor growth. Previously we showed that THs are able to regulate the antitumor immune response. Our aim was to evaluate the effect of thyroid status on the development of 4T1 breast carcinoma in syngeneic mice. For this, Balb/c mice were treated with thyroxine (12mg/l) for 30 days or propylthiouracil(500mg/l) for 15 days in the drinking water to obtain hyperthyroid (hyper) or hypothyroid (hypo) mice, respectively. Mice were theninoculateds.c with 4T1 cells. Hyper mice showed an increased tumor growth rate (p