THYROID HORMONES (THS) ACTING THROUGH INTEGRIN ΑVΒ3 INDUCE ONCOGENIC SIGNALING PATHWAYS INVOLVED IN T CELL LYMPHOMA (TCL) PROGRESSION

DEBERNARDI, MERCEDES; PAULAZO, ALEJANDRA; GONZALES, GONZALO; CAYROL, FLORENCIA; DIAZ ALBUJA, JOHANNA; DÍAZ FLAQUÉ, MARÍA CELESTE; ROSEMBLIT, CINTHIA; STERLE, HELENA; CAMPOS HAEDO, M.N.; CREMASCHI, GRACIELA A.

Congreso; REUNIÓN CONJUNTA SAIC SAI&FAIC SAFIS 2022; 2022

Decoding the molecular mechanisms leading to TCL progressionis a complex issue due to the diversity of these malignancies. Inmost TCL patients the JAK/STAT and NF-κB pathways are over-activated. To find new therapeutic targets, these oncogenic pathways,and the activating factors should be studied deeply. Our previousresults show that THs, acting via integrin αVβ3, promotes cell proliferation and survival, and induces an angiogenic program in TCLcells. Here we study if THs are one of the factors involved in theactivation of these oncogenic pathways. First, we analyzed TCL celllines corresponding to immature (CUTLL1) and mature (OCI-Ly12,OCI-Ly13.2) human subtypes after 10, 15, and 30 minutes THstreatment. We found that physiological levels of THs significantlyincrease STAT1, 3, 5, NF-κB, and ERK phosphorylation in all TCLcells (p