SOURCES OF INFECTION AND BLOODSTREAM ISOLATES IN PATIENTS WITH ACUTE LEUKEMIA: EXPERIENCE IN A UNIVERSITARY HOSPITAL.

VILLALBA PEDRO; MENDEZ GUSTAVO; SALVATIERRA KARINA; NIVEYRO CARLA

Congreso; European Hematology Association; 2020

Background: Patients with acute leukemia are at high risk of infections. The source of fever in this population of patientsis often not clinically evident. Despite early and aggressive empiric antimicrobial therapy and use of prophylacticantibiotics, infections remain a major cause of morbidity and mortality.Aims: To identify sources of fever and the type of pathogens that cause bloodstream infection (BSI) in patients with acuteleukemia (AL) and febrile neutropenia (FN) post cytotoxic chemotherapy.Methods: Retrospective observational study. All patients with AL (myeloid and lymphoid) and FN (absolute neutrophilcount of 7 days 77.82. Use of central venous catheter 34.13%. Gram-negative bacteria (GNB) werefound in 133 isolates (61.86%), Klebsiella pneumoniae 44.36% (ESBL 37.28%) y Escherichia coli 33.83% (ESBL11.11%) were the most frequent organisms. Gram-positive bacteria were found in 81 isolates (37.67%) CNS 43.20% and Staphylococcus aureus 33.33% were common. Abdominal (12.82%), respiratory (10.65%) and central venous catheter(CVC) infection (9.56%) were the most common sources. Neutropenia >7 days (OR, 5.59; 95% CI, 2.72-11.49 p