EXTRACTO DE ALCALOIDES DE HIPPEASTRUM STRIATUM (LAM.) H.E. MOORE: ANÁLISIS QUÍMICO Y ACTIVIDAD ANTIACETICOLINESTERÁSICA.

RODRIGUEZ MATA ORLANDO; HONFI ANA I.; ZARAGOZA J. D.; DAVIÑA JULIO R.; ORTIZ J. .; FERESIN G. E

SAN MIGUEL DE TUCUMAN

Congreso; XXXVII JORNADAS ARGENTINAS DE BOTANICA; 2019

SOCIEDAD ARGENTINA DE BOTANICA

The Amaryllidaceae species are extensively studied for their biological activities in several pharmaceutical areas. The genus Hippeastrum has deciduous leaves, tunicated bulbs, infl orescences with two to seven fl owers of different sizes and colors and is distributed from Argentina to Mexico and the Caribbean,contributing for more than 50 of the 448 alkaloids synthesized by the family. Among them, galanthamine is widely known to be a longacting, selective, reversible, and competitive acetylcholinesterase i nhibitor alkaloid, beingan important drug for the treatment of Alzheimer?s disease. As a part of the study of native Amaryllidaceae species from Argentina, the basic chloroform extract of Hippeastrum striatum (OR11, MNES), was obtained and evaluated for its inhibitory activity against acetylcholinesterase. The objective of this work was to confi rm the presence of the active galanthamine-type alkaloids galanthamine,sanguinine, and chlidanthine in the basic chloroform extract, and to evaluate its cholinesterase inhibitory activity. The thin layer chromatography analysis using reference standards of the three galanthamine-type alkaloids, showed the absence of them in the bulb extract. For the analysis of acetylcholin