Quorum sensing signals expressed by Burkholderia contaminans clinical isolates recovered from patients with cystic f

LEGUIZAMÓN, MARIANA; LEON, BELTINA; CASCO, DANIELA; RENTERÍA, FERNANDO; CAZZOLA, LAURA; BOSCH, MARÍA ALEJANDRA; PRIETO, CLAUDIA; BETTIOL, MARISA; VIGNOLLES, FLORENCIA; DIEZ, GRACIELA; PEREZ, S; MARTINA, PABLO; FÍGOLI, CECILIA; PALAU, JULIANA; MONTANARO, PATRICIA; YANTORNO, OSVALDO

SEVILLA

Conferencia; 40th EUROPEAN CYSTIC FIBROSIS CONFERENCE; 2017

EUROPEAN CYSTIC FIBROSIS SOCIETY

Burkholderia cepacia complex (Bcc) infection is associated with an accelerated decline in pulmonary function and an increased morbidity and mortality in patients with cystic fibrosis. Bcc bacteria are able to regulate the expression of several virulence factors by a cell-cell communication system known as quorum sensing (QS). QS involves the production of N-acyl-homoserine lactones (AHLs), which are signaling molecules that bind to transcriptional regulators and modulate gene expression. The CepIR QS system is a global regulatory system present in some of the Bcc species. It was reported that C8-HSL is the most common AHL signal express by some Bcc members. Particularly, species such as B. multivorans, B. cenocepacia and B. vietnamiensis synthesize C6-HSL, C4-HSL and C10-HSL respectively (Conway et al., 2002). However, the expression of AHLs by B. contaminans has not been reported, so far.The aim of the present work is to get insights into the QS signals expressed by B. contaminans clinical isolates recovered along the chronic infection of patients with cystic fibrosis.