Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis

ARGüELLES, CARINA; REINA, SILVIA; RUDZINSKI, MARCELO; COUTO, CRISTóBAL; OUBIñA, JOSé R.

OCULAR IMMUNOLOGY AND INFLAMMATION

Taylor and Francis Ltd

Lugar: Tubingen; Año: 2018

0927-3948

Purpose: The purpose of this article is to analyze possible associations between systemic and ocular cytokine levels and specific clinical ophthalmologic signs from patients with a reactivation of toxoplasmic retinochoroiditis (RTR). Methods: A total of 18 patients with an active RTR episode, 8 patients with inactive scars, and 14 control patients were included in the study. Serum samples and aqueous humor (AH) samples were analyzed for IFN (interferon)-ã, interleukin (IL)-10, and IL-6 levels by ELISA. Inflammation grade, location, and size of the retinochoroidal active lesion, sampling time, and time to resolution were recorded. Results: A significantly negative correlation between AH and serum levels of IFN-ã was detected (p