IBBEA   24401
INSTITUTO DE BIODIVERSIDAD Y BIOLOGIA EXPERIMENTAL Y APLICADA
Unidad Ejecutora - UE
artículos
Título:
Murine sperm capacitation, oocyte penetration and decondensation following moderate alcohol intake
Autor/es:
GALLOTO CAMILA; CALVO LUCRECIA; SANCHEZ MELISA; CAMBIASO MAITE; CALVO JUAN CARLOS; FONTANA VANINA; SOBARZO CRISTIAN; CEBRAL ELISA
Revista:
REPRODUCTION
Editorial:
BIOSCIENTIFICA LTD
Referencias:
Lugar: Bristol; Año: 2018 vol. 155 p. 529 - 541
ISSN:
1470-1626
Resumen:
Male chronic alcohol abuse causes testicular failure and infertility. We analyzed the effects of moderate sub-chronic alcohol intake on sperm morphology, capacitation, fertilization and sperm head decondensation. CF-1 male mice were administered 15% ethanol in drinking water for 15 days; control mice received ethanol-free water. Similar patterns of tyrosine phosphorylation were observed in capacitated spermatozoa of control and treated males. Percentage of hyperactivation (H) and spontaneous (SAR) and progesterone-induced (IAR) acrosome reaction significantly decreased at 120 and 150 minutes of capacitation in treated males compared to controls (H: 14.1 ± 2.5 vs 23.7 ± 2.6, p