INVESTIGADORES
DELGADO Monica Alejandra
artículos
Título:
The RcsCDB regulatory system plays a crucial role in the protection of Salmonella enterica serovar Typhimurium against oxidative stress
Autor/es:
FARIZANO JV; TORRES, M.A; PESCARETTI MM,; DELGADO, M. A.
Revista:
MICROBIOLOGY-UK
Editorial:
SOC GENERAL MICROBIOLOGY
Referencias:
Lugar: London; Año: 2014 vol. 160 p. 2190 - 2199
ISSN:
1350-0872
Resumen:
Dps, the most abundant protein during the stationary growth phase, in Salmonella enterica is required for resistance to reactive oxygen species produced by the host during infection. It has been reported that in Salmonella dps expression is controlled by RpoS and Fur proteins. However, the regulation and function of Dps remain to be resolved. In the present work we demonstrate that activation of the complex RcsCDB regulatory system increases dps expression during exponential growth of Salmonella. In addition, we show that such dps upregulation produces high levels of H2O2 resistance. This phenotype allows the bacteria to avoid reactive oxygen species killing at early stages of growth, thus protecting its genetic material.