Distinctive EBV infection characteristics in children from a developing country

FERRESSINI GERPE, NM; VISTAROP, AG; MOYANO, A; DE MATTEO, E; PRECIADO, MV; PAOLA ANDREA CHABAY

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES : IJID : OFFICIAL PUBLICATION OF THE INTERNATIONAL SOCIETY FOR INFECTIOUS DISEASES.

ELSEVIER SCI LTD

Año: 2020

1201-9712

Background: In developing countries, Epstein-Barr virus (EBV) infection is mostly asymptomatic in early childhood. EBVpersistence may lead to different malignancies, such as B cell derived lymphomas. In Argentina, most children are seropositive at three years and an increased association between EBV and lymphoma was proved in children under 10 years old by our group. Objective:Our aim was to characterize EBV infection at the site of entry and reactivation of viral infection -the tonsils- in order to better understand the mechanism of viral persistence in pediatric patients. Methods:A cohort of 54 patientswas described. We assessed specific antibodies profile in sera; viral proteins presence by IHC on FFPE samples and EBV type from fresh tissue.Results:EBV type 1 was prevalent, mostly in the youngest. Asymptomatic primary infected patients presented higher viral loads and Latency 0/I or II patterns, whereas Latency III pattern was observed mostly in healthy carriers. There were no differences between groups in the expression of viral lytic antigens. This study discloses new features in patients undergoing primary infection from a developing population. Low viral inoculum and restricted viral antigen expression may be responsible for the lack of symptoms in children from our country.