Demonstration of Epstein-Barr virus in carcinomas of various sites.

GRINSTEIN, S.; PRECIADO, M. V.; GATTUSO, P.; PAOLA ANDREA CHABAY; WARREN, W.; DE MATTEO, E; GOULD, V.

Cancer Research

American Association for Cancer Research

Año: 2002 vol. 62 p. 4876 - 4878

0008-5472

Epstein-Barr virus is etiologic in infectious mononucleosis, is implicated in some malignant lymphomas, and LELC, and has been sporadically reported in carcinomas of the breast, lung, and other sites.   We studied immunohistochemically benign and malignant tumors of the breast, lung, colon and prostate, and found EBV in some carcinomas of those sites.  Also, EBV reactions were noted in hyperplasias and dysplasias e.g. breast carcinomas in situ, and PIN.  Benign tumor counterparts were negative.  PCR analysis of selected cases confirmed the presence of EBV. Our results suggest that EBV is not restricted to LELC but may play an oncogenic role in frequent epithelial cancers, and  possibly also in hyperplasias and certain dysplasias preceding carcinomas