Epstein Barr Virus (EBV) Association and Latency Profile in Paediatric Burkitt Lymphoma: Experience of a Single Institution in Argentina

LARA, J; COHEN, M; DE MATTEO, E; AVERSA, L.; PRECIADO, M. V.; PAOLA ANDREA CHABAY

JOURNAL OF MEDICAL VIROLOGY

WILEY-LISS, DIV JOHN WILEY & SONS INC

Lugar: New York; Año: 2014 vol. 86 p. 845 - 850

0146-6615

The aim of this study is to characterise EBV expression and latency pattern in paediatric Burkitt lymphoma in a single institution in Argentina. EBV-encoded RNA or protein was analyzed in 27 patients. EBERs was expressed in 37% of patients (29% of immunocompetent and 100% of immunosuppressed patients). EBV-positive cases were observed exclusively in patients younger than 5 years old. EBV association with immunocompetent patients exhibits the sporadic pattern in region under study, while its presence in patients infected with HIV was higher than described previously. EBV latency I profile was present in most of the patients, except for 2 immunosuppressed patients who displayed LMP1 expression.