CENTRO DE INVESTIGACION Y DESARROLLO EN INMUNOLOGIA Y ENFERMEDADES INFECCIOSAS
Unidad Ejecutora - UE
capítulos de libros
Study of Eosinophil Apoptosis Induced by Fasciola hepatica Excretory?Secretory Products
GUASCONI, LORENA; DIANA T. MASIH; CERVI, LAURA; MARIANELA DEL CARMEN SERRADELL; CHIAPELLO, LAURA
Fasciola hepática. Methods in Molecular Biology
Lugar: New York; Año: 2020; p. 133 - 148
The excretory-secretory products released by the liver fluke Fasciola hepatica (FhESP) are in close contact with the immune system and have different immunomodulatory effects associated with the parasite virulence. The control of the early immune response is crucial for the establishment of the fluke in the host. Related to this, eosinophils (Eo) are implicated as effector cells in helminthic infections, and the induction of Eo apoptosis has been demonstrated to be a remarkable immunoevasion mechanism induced by the parasite. In this chapter, we describe different techniques to assay Eo apoptosis triggered by FhESP as well as the mechanisms involved in this phenomenon.