CIDIE   24052
CENTRO DE INVESTIGACION Y DESARROLLO EN INMUNOLOGIA Y ENFERMEDADES INFECCIOSAS
Unidad Ejecutora - UE
artículos
Título:
Early Detection of Chronic Asymptomatic Chagas Infection
Autor/es:
DE LA ROSA, E; TRIQUELL, MF; FERNÀNDEZ, EA; PAGLINI OLIVA, P; BENIZIO, E; PRATO, L; MUÑOZ, SE
Revista:
MEDICAL SCIENCE MONITOR
Editorial:
INT SCIENTIFIC LITERATURE, INC
Referencias:
Lugar: New York; Año: 2018 vol. 24 p. 4567 - 4571
ISSN:
1234-1010
Resumen:
Chagas disease, also known as American trypanosomiasis, is a chronic and systemic parasitic infection whichhas become a serious epidemiological problem not only in endemic regions (Latin America), but also in nonendemicones like North America, Europe, and Oceania. Subjects with the indeterminate chagasic form (ICF),a chronic asymptomatic disease stage, are the main sources of non-vectorial dissemination through blood transfusion,organ transplantation, and congenital transmission. It has been suggested that 94% of urban infectionscan be explained by these subjects. Under this scenario, the availability of simple and effective screeningmethods for ICF detection becomes crucial for both prevention of disease propagation and detection of clinicalstages. Recently, a new non-invasive method has been proposed for ICF detection. It is based on surfacehigh-resolution ECG and it could be easily adopted and included in modern ECG devices, overcoming the limitationsof serological-based tests. The proposed method shows accuracy for early ICF screening, thus improvingprognosis by defining the clinical stages and allowing appropriate and effective treatment.