Rol of estrogen-related receptor alpha and estrogen receptor alpha on transcriptional regulation of Acyl-CoA synthetase 4 in breast cancer cells.

LOPEZ P.; ORLANDO U.; DATTILO MA.; HERRERA L.; CASTILLO A. ; BENZO Y. ; PRADA J. ; MALOBERTI PM.

Congreso; LXIV Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica; 2019

Acyl-CoA synthetase 4 (ACSL4) overexpression plays a causal role in the aggressiveness of triple negative breast cancer (TNBC). In turn, a negative correlation has been established between ACSL4 and estrogen receptor alpha (ERα) expression. Our hypothesis is that transcriptional regulation is involved in the differential expression of ACSL4 in breast cancer cells. We observed that TNBC cells (MDA-MB-231 and Hs578T) exhibit greater activity of ACSL4 promoter than ERα+ cell lines (MCF-7 and T47D) (p