INBIOMED   24026
INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Placental dysmorphology and abnormal angiogenesis at mid- and late gestation following maternal alcohol consumption in mouse
Autor/es:
GUALDONI G; CEBRAL, E.; VENTUREIRA, MR; BARBEITO C
Lugar:
Cordoba
Reunión:
Congreso; IXI LASBRA International Meeting; 2019
Resumen:
From mid-gestation onwards, the placenta is the essential organ for supplying nutrients and oxygen to embryo-fetal development. Since placental defects correlate strongly with abnormal brain, heart and vascularization, the embryo-fetal developmental disorders after maternal alcohol ingestion may be linked to placental dysmorphology and abnormal angiogenesis at or after mid-gestation. We aimed to evaluate wether perigestational alcohol consumption up to early organogenesis (day 10 of gestation, D10), in mouse, alters placentation and disrupts vascular endotelial growth factor (VEGF) system of trophoblastic tissue at mid and later gestation. Murine CF-1 females were administered with ethanol 10% in drinking water (25% EDC) for 15 days previous and up to D10, or gestation continued with water until D13 (treated females, TF). Control females (CF) were administered with drinking water without ethanol. At D10, the implantation sites from TF had diminished trophoblastic growth, cellular and tissue defects, and poor labyrinthine vascularization detected by deficient invagination of allantoic blood vessels into the chorionic ectoderm (H-E, PAS). In the labyrinth of TF, VEGF immunoexpression was reduced while the receptor KDR expression was increased compared to controls (p