INBIOMED   24026
INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A retrospective analysis of protocol review: three years of IBYME-IACUC
Autor/es:
MORALES, ROSA MARÍA; GULIN, ERNESTO; BOTO, AMALIA; VASTA, NATALIA; SANITÁ, GRACIELA
Lugar:
Mar del Plata
Reunión:
Otro; Reunión Anual de Sociedades Biocientíficas.; 2019
Institución organizadora:
SAIC-SAFE-SAB-SAP-AACYTAL-NANOMEDar-HCS
Resumen:
The Instituto de Biología y Medicina Experimental Institutional Animal Care and Use Committee (IBYME-IACUC) oversees laboratory animal welfare in research and reviews the protocols involving animals used at the institution. The lack of a National Law aiming at regulating and protecting the use of animals for educational and research purposes undermines a strict control on the procedures.Moreover, not only national and international funding agencies but also most of the peer-reviewed scientific journals require an IACUC approval. In 2016, the Committee Board at IBYME appointed an internal IACUC, composed of a veterinarian, laboratory animal technologists, research scientists from different disciplines and community representatives. This work aims to report the key issues dealt with while reviewing and approving the protocols submitted to the IBYME-IACUC during 2016-2018. Along this 3-year period, 150 protocols were submitted and 144 were finally approved (2016= 57; 2017= 57; 2018= 30). Themain areas were represented as follows: cancer constitutes 31%, reproduction 27 % while immunology, neurosciences and endocrinology include 13 % of the projects submitted, allocated jointly to these three areas, and 3 % for other categories. The most used animal species were mice (Mus musculus) in 82 % of the protocols, followed by rats (Rattus norvegicus) (13 %) and 5 % of other species. Regarding mice strains, most protocols employed C57BL/6 or BALB/c. The severity classification of the procedures was based on EU Directive (2010/63). Thus,procedures classified as mild or moderate were 42 %, while 10 % were severe, 3 % with no recovery or mild and 3 % had no recovery. Considering the lack of local database on the use of laboratory animals, this work provides updated information of the local scenario of animal use for research and may contributeto developing long term scientific policies that ensure the welfare of animals used in research to help fulfill IACUC?s responsibilities in Argentina.