INBIOMED   24026
INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Pituitary Activin System During Postnatal Development
Autor/es:
DÍAZ-TORGA, G; FARAONI, E; PISERA D; ABELEDO-MACHADO A; FERRARIS J; CAMILLETI, MA
Lugar:
Ciudad de Buenos Aires
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
Activin is a known inhibitor of lactotroph, somatotroph and gonadotroph function which action is inhibited by inhibins and follistatin (FST). Activins are homodimers of β chains A and B, giving rise to Activin A (βA-βA), B (βB-βB) or AB (βA-βB). Activin binds to receptors type II (ActRII or ActRIIB) and type I (ActRI/ALK4), inducing direct phosphorylation of Smad2/3. The aim of the present work was to study the ontogeny of pituitary activin system in males and females Sprague Dawley rats at different ages: 11, 23 and 45 days. Adult females were used in diestrus. The expression of the components of the activin system was evaluated by qPCR. Statistical analysis: Two-Way ANOVA, followed by post hoc Tukey test. In general, all components evaluated (βA, βB, ActRII, ActRIIB, and FST) showed a significantly high mRNA expression in 11-day pups, and decreased with age. In addition, we found interesting gender differences; in 11 days old pups, pituitary expression of all components was found significantly increased in female compared to male rats (p