Subtype 3 metabotropic glutamate receptor-induced amyloid-beta clearance by glial cells

DANIELA DURAND; JUAN TURATI; MERCEDES LASAGA; DELIA RAMIREZ; CARLA CARUSO; LILA CARNIGLIA; JULIETA SABA

CABA

Congreso; 2nd FALAN Congress; 2016

FALAN

Previous results from our group reveal that stimulation of astroglial mGlu3 receptors promotes the non?amyloidogenic cleavage of amyloid precursor protein. This action implies both, increased neurotrophic sAPPa peptide levels and decreased Ab production. But anti-amyloid effects of glial mGlu3R are apparently not restricted to the Ab synthesis pathway. Indeed, we show here that Ab clearance is also regulated by these receptors. mGlu2/3R agonist LY379268 (0.1 uM) induced not only microglial ingestion of latex beads (p