The effect of IL-beta on memory reconsolidation is mediated by a reduction of glutamate release, calcium influx and AMPA phosphorilation. Modulation by alpha-MSH.

MACHADO I; GONZALEZ P; VILCAEZ A; LASAGA M; SCIMONELLI T

Washington

Congreso; Annual Meeting Society for Neuroscience, Washington, USA, Noviembre de 2014.; 2014

SFN

The immune system is an important modulator of learning, memory and neural plasticity. Interleukin 1b (IL-1b), a pro-inflammatory cytokine, significantly affects several cognitive processes. Previous studies of our group have demonstrated that the intrahippocampal administration of IL-1b impairs reconsolidation of contextual fear memory. This effect was reversed by the melanocortin alpha-melanocyte-stimulating hormone (a-MSH). The mechanisms underlying the effect of IL-1b on memory reconsolidation have not been established yet. Our results demonstrate that IL-1b produced a significant decrease of glutamate release after reactivation of the fear memory. This effect would be related to diminished calcium influx in the presynaptic terminal induce by IL-1 b. The intrahippocampal administration of a-MSH can reverse these effects. Our results establish a possible mechanism involved in the detrimental effect of IL-1b on memory reconsolidation and also that a-MSH may exert a beneficial modulatory role in preventing IL-1b effects.