INBIOMED   24026
INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ESTROGENS PROMOTE GH3 SOMATOLACTOTROPE CELL SURVIVAL THROUGH NUCLEAR FACTOR KAPPA B (NF-κB) PATHWAY
Autor/es:
EIJO G; MORENO AYALA MA; JAITA G; ZÁRATE S; MAGRI ML; CANDOLFI M; GOTTARDO MF; FERRARIS J; PISERA D; SEILICOVICH A
Lugar:
San Francisco
Reunión:
Congreso; 95th Annual Meeting of the Endocrine Society; 2013
Resumen:
Activation of Nuclear Factor kappa B (NF-êB) promotes cell proliferation and inhibits apoptosis. In several cell lines, including GH3 pituitary cells, NF-êB activity is constitutive and sustained. We have previously shown that estrogens inhibit TNF-á- induced NF-êB nuclear translocation in anterior pituitary cells from primary cultures, suggesting that this mechanism participates in the sensitizing action of estrogens in the pro-apoptotic effect of TNF-á on these cells. Now, we report the effect of estrogens on TNF-á-induced NF-êB nuclear translocation and apoptosis in GH3 cells. As determined by Western blot, estradiol increased nuclear concentration of NF-êB/p105, p65 and p50 in GH3 cells (p