Reduced cAMP levels, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes.

DURAND D; CARNIGLIA L; CARLA CARUSO; LASAGA M

Buenos Aires

Simposio; 2do Simposio Franco-Argentino de Neurociencias; 2012

UBA-CONICET

Subtype 3 of metabotropic glutamate receptors (mGluR3) is present in astrocytes, its activation exerting neuroprotective roles against astrocyte death induced by nitric oxide (NO) [Durand et al., 2010]. However, mechanisms responsible for that cytoprotective property are still subject to study. Although inhibition of adenylyl cyclase by mGluR3 activation was extensively reported, the involvement of reduced cAMP levels in the effects of mGluR3 agonists and the association between cAMP decrease and the downstream pathways activated by mGluR3 remain neglected. Thus, we studied intracellular signaling mediating anti-apoptotic actions of mGluR3 agonists LY379268 and LY404039 in cultured rat astrocytes exposed to NO.