TARGETING FOXP3 TUMOR INTRINSIC EFFECTS USING ADENOVIRAL VECTORS IN EXPERIMENTAL BREAST CANCER

ALEJANDRO J. NICOLA CANDIA; MELANIE PÉREZ KÜPER; ADRIANA SEILICOVICH; MARIANELA CANDOLFI; JORGE A. PEÑA AGUDELO; NOELIA CASARES; FLAVIA A. ZANETTI; MATÍAS GRACÍA FALLIT; NAZARENO GONZALEZ; JUAN JOSÉ LASARTE

Mar Del Plata

Otro; Reunion anual de sociedades de biociencia; 2023

Regulatory T cell master transcription factor, Forkhead box P3 (Foxp3) has been detected in cancer cells, but its role in breast tumor pathogenesis remains controversial. Here we assessed Foxp3 tumor intrinsic effects in experimental humen breast cancer cells using a Foxp3 binder peptide (P60) that impairs Foxp3 nuclear translocation. Foxp3 expression varies among triple negative breast cancer (TNBC) cells, being higher in MDA-MB-468 (60%), than in MDA- MB-231 (25%). Nevertheless, Cisplatin upregulated the Foxp3 expression in MDA-MB-231 (43%; p