INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
TWENTY YEARS OF EXPERIENCE WITH PATERNAL IMMUNOTHERAPY: A ROLE AS AN ENHANCER OF THE IN VITRO FERTILIZATION
Autor/es:
VERÓNICA GONZÁLEZ; FERNANDEZ PABLO; LEONARDO FAINBOIM; SANTIAGO BELEN
Lugar:
Buenos Aires
Reunión:
Congreso; LXVIII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA (SAI); 2020
Resumen:
Unexplained Recurrent Spontaneous Abortion (URSA) is a common pregnancy complication that implies loss within the first 20 weeks of gestation. Immunological mechanisms seem to participate in their development. Unexplained infertility has also been associated with these mechanisms. Paternal immunotherapy (PIT) is used worldwide as treatment for URSA, but protocols differ mainly in amount of mononuclear cells, routes of administration, or single versus several doses. Herein we report results from the use of PIT in a cohort of 416 primary URSA, 92 secondary URSA and 298 infertile women. All patients followed a multiple intra-dermal injection of paternal mononuclear cells until detection of more than 50% blocking activity in a mixed lymphocyte reaction (MLR-Bf). Patients and controls were followed during 2 years since their first consultation. Statistical comparisons were done by two-tailed unpaired t-test and Fisher?s exact test, considering differences significant when P