INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Brucella abortus-infected platelets modulate neutrophil activation
Autor/es:
TROTTA, ALDANA; CASTILLO LUIS; FERNÁNDEZ GABRIELA CRISTINA; SERAFINO A; DELPINO, M. VICTORIA; MILILLO, M. AYELÉN; BIRNBERG WEISS, FEDERICO; BARRIONUEVO, PAULA
Lugar:
San Miguel de Tucuman
Reunión:
Congreso; LXVII Reunión Científica anual SAI; 2019
Institución organizadora:
SAI
Resumen:
Brucellosis is an infectious disease elicited by bacteria of Brucella genus. Platelets have been extensively involved in the modulation of innate and adaptive immune responses. We have previously reported that platelets can modulate the B. abortus-mediated infection of monocytesincreasing their pro-inflammatory capacity, which promote the resolution of the infection. On the other hand, we have demonstrated that B. abortus is able to activate neutrophils at sites of infection. Thus, we wondered whether platelets are able to interact with neutrophils and/or modulate their activation. We first studied whether neutrophils stablish complexes with platelets. Our results showed that B. abortus was able to increase the percentage of neutrophils bound to platelets (p