Hipopara-red, real life experience in 322 patients with hypoparathyroidism in Argentina

OLIVERI B; KARLSBRUM S; LUCAS S; TORMO S; ROBBIANI D; FRIGERI A; PEREZ B; GRANDJEAN M; GALICH AM ; ZANCHETTA MB; GIACOIA E; SALERNI H; DIAZ A; KIITAIGRODSKY A

Congreso; World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases; 2019

Hypoparathyroidism (HPT) is a rare disorder characterized by hypocalcemia and absent or deficient PTH. It is associated with an increased risk of various complications, but only a few data are available on the natural history and correct management of this disease.Aim: Describe clinical characteristics, treatment, and complications in a group of patients withhypoparathyroidism from 6 referral centers for endocrinological diseases, with expertise inhypoparathyroidism, in Argentina. Secondary, describe how many patients reached guidelinesrecommendations for rhPTH (1-84) treatment (Brandi ML. JCEM. 2016).Materials and Methods: In this retrospective study patients with a diagnosis of HPT of ≥6 months were eligible for inclusion. Patients with pseudohypoparathyroidism were excluded. Demographics, etiology, management, hospitalizations, clinical manifestations (fracture history, seizures, kidney stones, basal ganglia calcification, between others), and biochemical and DXA values were collected. Results:322 HPT patients were included; mean age was 55.2 ± 16.8 years, 85,7% were women. Mean age at diagnosis was 43.8 ± 16.8 years and mean follow up time was 4.9 ± 5.1 years. Regarding etiology 90% were post-surgical (50.3% for thyroid cancer, 41% for multinodular goiter, 2.7% primary hyperparathyroidism; 3.4% secondary hyperparathyroidism and 2.3% cervical cancer). Non-surgical etiology included: 5 DiGeorge Syndrome, 9 autoimmune and 16 idiopathic. Non-surgical patients were significantly younger (45 ± 19.5 vs.56.3 ± 16.1 years; p