INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Variation of the absolute telomere length after different treatment in patients with obesity
Autor/es:
MILLÁN, ANDREA LILIANA; CERRATO GARCÍA, MARTINA; FRECHTEL, GUSTAVO DANIEL; PAUTASSO, CONSTANZA; ROJO, MAILÉN; CERRONE, GLORIA EDITH; IGLESIAS MOLLI, ANDREA ELENA; GUTT, SUSANA
Lugar:
Mar del Plata, Buenos Aires
Reunión:
Congreso; Reunión anual de Sociedades de Biociencia; 2019
Institución organizadora:
SAIC, SAFE, SAB, SAP, con participación de NANOMED-ar, AACYTAL, y HCS.
Resumen:
Overweight and obesity are one important risk factors for mortality in the world. Telomeric length is considered a marker of cell aging and is closely related to biological situations like oxidative stress and inflammation. Our objective was to analyze different treatments on absolute telomere length (aTL) in obese patients. We studied a group of 21 patients with obesity treated with diet, physical exercise and pharmacological treatment and a group of 31 obese patients with indication of bariatric surgery. The biochemical-clinical characteristics were measured and we evaluated the difference in their absolute telomere length after 6 months of intervention. aTL was determined in genomic DNA extracted from peripheral blood leukocytes by the method of absolute quantification by quantitative real-time PCR. Statistical analysis was carried out by SPSS with a significance level of 0.05. We observed by linear regression a negative association between the variation of aTL between basal time and after 6 months and age in all patients with obesity (p= 0.03). A change in telomere length significantly correlates with weight loss (p= 0.01) and decrease in BMI (p