INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Comparison of deproteinized bovine bone, bioglass and, synthetic hydroxyapatite in the bone healing of a critical sized bone defect. Preliminary study in rats.
Autor/es:
PELLEGRINI GG; ZENI SN; GONZALES CHAVES MMS; ORZUZA R
Lugar:
Mar del Plata
Reunión:
Congreso; Reunion Anual de la SAIC; 2019
Institución organizadora:
SAIC
Resumen:
Bone grafts are important for alveolar bone height and volume preservation necessary for dental implant placement. The development of biomaterials for bone grafting with comparable characteristics and 
biological effects than those renowned internationally is necessary. Deproteinized bovine bone putty (BB), bioglass (BG) and, synthetic hydroxyapatite (SH) are frequently indicated as bone grafting materials due to their osteoconductive properties. We compared the bone healing response of BB, BG and SH (Odontit Implant Systems, Argentina) in a critical sized bone defect. We created a bone defect of 4 mm diameter in rat tibiae for implantation with each biomaterial (N=30 rats). Samples were collected at 2 and 4 weeks for histological and histomorphometrical analysis of new bone formation (NBF) and remaining particles of each device (RP). Radiographic analysis was done at T=0 and at 2 and 4 weeks. Results: % of NBF (mean ± SD): 2 weeks: Control group: 6.60±3.71; BB group: 23.23±3.89*; BG group: 18.35±5.23*; SH group: 26.27±9.30*; 4 weeks: Control group: 6.69±2.38; BB group: 24.37±3.66*; BG group: 17.45±6.64*; SH group: 32.25±3.80*. % of RP: 2 weeks: Control group: 0±0; BB group: 5.04±1.39*; BG group: 3.03±2.31*; SH group: 4.46±2.87*; 4 weeks: Control group: 0±0; BB group: 4.45±2.35*; BG group: 2.87±1.14*; SH group: 3.78±1.68* (*p