INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Analysis of telomer length in women with polycystic ovary syndrome.
Autor/es:
ANDREA MILLAN; SILVINA COCUCCI; GUSTAVO FRECHTEL; MARIELA VELAZQUEZ ; ANDEA MOLLI; ALICIA BEATRIZ MOTTA; GISELLE ADRIANA ABRUZZESE; MABEL GRAFFIGNA; GLORIA CERRONE
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión conjunta SAIC, SAI y SAFIS 2018. LXIII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC).; 2018
Institución organizadora:
Sociedad Argentina de Investigación Clínica (SAIC)
Resumen:
Polycystic ovary syndrome (PCOS) is the most common endocrinedisorder affecting women in their reproductive age. We aimed to determinethe absolute LT (LTa) in women with PCOS in comparisonwith healthy controls and their association with metabolic variablesand the presence of hyperandrogenism.We analyzed 86 control women and 130 PCOS patients (16-46 yearsof age). Measurements of biochemical, clinical, anthropometric andhormonal variables were made. Biochemical hyperandrogenism(HA) presence was determined (total testosterone levels higher than0.9ng/mL). LTa determination was performed on genomic DNA fromperipheral blood leukocytes by Real Time PCR absolute quantitativemethod. The relationship kpb of telomeric sequences and copies ofthe single copy gene RPLPO (radio T/S) was determined. Statisticalanalysis were carried out by one-way ANOVA and linear regression.PCOS patients have a higher weight, body mass index (BMI), greaterwaist circumference (WC), higher levels of triglycerides (TG), andfasting plasma glucose as compared to controls. An inverse relationshipwas observed between LTa and age (p=0.004). PCOS patientspresented increased LTa as compared to controls (p=0.001, adjustedfor age: p=0.005). Moreover, we found higher levels of LTa in PCOSHAwomen as compared to PCOS-NHA and Controls (p=0.004). InPCOS patients, we found an association between higher LTa andlower BMI (p=0.040), lower WC (p = 0.004), lower TG levels (p =0.049), lower DPB (p=0.001) and higher c-HDL (p=0.004).In conclusion, LTa presents an inverse relationship with age in thestudied population. The significantly increased LTa in PCOS patients(as compared to controls) could be a consequence of the presenceof different metabolic, but mainly, hormonal components. A lowerLTa was associated with presence of metabolic syndrome components,while biochemical HA was associated with higher LTa. Ourresults contribute to knowledge about the role of LT in the pathophysiologyof PCOS.